⦁ The Athletics started their first-ever Western road trip with a ten-inning, 9-5 win over the White Stockings in Chicago
⦁ Socks Seybold tied the game in the ninth for the A's with a two-run single and the A's scored four more in the top of the tenth to win it
⦁ Rain delayed the start of the game and there were further showers in the third and sixth innings, but not enough to cause a stoppage of play
⦁ Harry Davis made his A's debut at first base, going 1-for-4 with a double
⦁ In Sporting Life, Francis Richter reported that manager Connie Mack was after three California League players: pitchers George Babbitt and Oscar Jones, and shortstop Harry Krug
• Shortstop Harry Lochhead released on or around this date
| May 22, 1901 | |||||||||||||||
| Philadelphia Athletics (6-14) at Chicago White Stockings (16-7) | |||||||||||||||
| 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | R | H | E | |||
| PHL | 0 | 2 | 0 | 1 | 0 | 0 | 0 | 0 | 2 | 4 | - | 9 | 13 | 2 | |
| CHI | 0 | 0 | 0 | 0 | 1 | 4 | 0 | 0 | 0 | 0 | - | 5 | 7 | 2 | |
| Ballpark | South Side Park | ||||||||||||||
| City | Chicago, Illinois | ||||||||||||||
| Attendance | 1,200 | ||||||||||||||
| Managers | Connie Mack (PHL), Clark Griffith (CHI) | ||||||||||||||
| Starting pitchers | Wiley Piatt (PHL), John Skopec (CHI) | ||||||||||||||