After two days of rain delays, the Athletics were finally able to open their regular season, but lost to the Senators, 5-1, at Columbia Park. Roughly 15,000 were in attendance—about 10,000 of whom paid their way in—and 3,000 more were turned away at the gate.

Chick Fraser had the honor of starting the first-ever Athletics game that counted, walking four and striking out five. Because April had been so rainy there was still no grass in the outfield. The A's scored their only run in the seventh when Socks Seybold drove in Nap Lajoie from third.